How Heidelberger and Avery sweetened immunology
نویسنده
چکیده
In 1923, a young chemist-turned-microbiologist and his mentor made the startling discovery that bacterial sugars could be targeted by the immune system--a groundbreaking finding that helped launch the field of immunochemistry.
منابع مشابه
Heidelberger and the demystification of antibodies
Heidelberger and Avery’s early experiments hinged on a simple element: nitrogen. Based on its presence or absence, the duo showed that the antibody-reactive substances on pneumococcal bacterial capsules were nitrogen-free carbohydrates, and that the reacting antibodies were nitrogencontaining proteins (see “How Heidelberger and Avery sweetened immunology” JEM 202:1306). The discovery that antib...
متن کاملMichael Heidelberger and the demystification of antibodies
Heidelberger and Avery’s early experiments hinged on a simple element: nitrogen. Based on its presence or absence, the duo showed that the antibody-reactive substances on pneumococcal bacterial capsules were nitrogen-free carbohydrates, and that the reacting antibodies were nitrogencontaining proteins (see “How Heidelberger and Avery sweetened immunology” JEM 202:1306). The discovery that antib...
متن کاملMichael Heidelberger and the demystification of antibodies
Having defined the protein nature of antibodies under the tutelage of Oswald Avery, Michael Heidelberger was the first to apply mathematics to the reaction of antibodies and their antigens (the "precipitin reaction"). Heidelberger's calculations launched decades of research that helped reveal the specificity, function, and origin of antibodies.
متن کاملThe Soluble Specific Substance of Friedländer's Bacillus
1. Methods are given for the isolation of specifically reacting nitrogen-free polysaccharides from Type A and Type C Friedländer's bacillus. 2. The properties of these specific carbohydrates have been outlined.
متن کاملImmunological Relationships of Cell Constituents of Pneumococcus
In this paper the general immunological significance of the intact pneumococcus cell and of its protein and carbohydrate components is discussed.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 202 شماره
صفحات -
تاریخ انتشار 2005